*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YX9822000
CHEMICAL NAME           : Verrucarin A, 2',3'-didehydro-2'-deoxy-
CAS REGISTRY NUMBER     : 4643-58-7
LAST UPDATED            : 198706
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C27-H32-O8
MOLECULAR WEIGHT        : 484.59
WISWESSER LINE NOTATION : T B-18-56 C6 A 2BC D& AX CX EOV KOV QVO VO GU MU OU
                          A&UTJ H1 A-& BT3OX CHJ
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * 2',3'-Didehydro-2'-deoxyverrucarin A
   * Muconomycin B
   * Verrucarin J
   * Verrucarin J, stereoisomer
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   15,262,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 6,198,1981
 
                            *** END OF RECORD ***