*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YX3992800
CHEMICAL NAME           : Venom, snake, Naja nivea
LAST UPDATED            : 199209
DATA ITEMS CITED        : 16
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Geel kapell venom
   * Naia nivea venom
   * Naja nigra venom
   * Naja nivea venom
   * Vipera flava venom
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 ng/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJEHAA Quarterly Journal of Experimental Physiology (1957).  (London, UK)
   V.1-27, 1920-38.  For publisher information, see QJEPAY.
   Volume(issue)/page/year: 20,7,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 900 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 23,63,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 334 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 29,1315,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 5,47,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 389 ug/kg
TOXIC EFFECTS :
   Blood - change in clotting factors
REFERENCE :
   23EIAT "Venomous Animals and Their Venoms," Buecherl, W., and E.E. Buckley,
   eds., 3 vols., New York, Academic Press, Inc., 1968-71
   Volume(issue)/page/year: 1,437,1968
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30FDAB "Neuropoisons: Their Pathophysiological Actions, 1971-1974," Simpson,
   L.L., and D.R. Curtis, eds., New York, Plenum Pub. Corp., 1974
   Volume(issue)/page/year: 1,21,1971
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 3500 ng/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   QJEHAA Quarterly Journal of Experimental Physiology (1957).  (London, UK)
   V.1-27, 1920-38.  For publisher information, see QJEPAY.
   Volume(issue)/page/year: 20,7,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 1500 ng/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   QJEHAA Quarterly Journal of Experimental Physiology (1957).  (London, UK)
   V.1-27, 1920-38.  For publisher information, see QJEPAY.
   Volume(issue)/page/year: 20,7,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 150 ng/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   QJEHAA Quarterly Journal of Experimental Physiology (1957).  (London, UK)
   V.1-27, 1920-38.  For publisher information, see QJEPAY.
   Volume(issue)/page/year: 20,7,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 140 ng/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJEHAA Quarterly Journal of Experimental Physiology (1957).  (London, UK)
   V.1-27, 1920-38.  For publisher information, see QJEPAY.
   Volume(issue)/page/year: 20,7,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 200 ng/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJEHAA Quarterly Journal of Experimental Physiology (1957).  (London, UK)
   V.1-27, 1920-38.  For publisher information, see QJEPAY.
   Volume(issue)/page/year: 20,7,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 1250 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30FDAB "Neuropoisons: Their Pathophysiological Actions, 1971-1974," Simpson,
   L.L., and D.R. Curtis, eds., New York, Plenum Pub. Corp., 1974
   Volume(issue)/page/year: 1,21,1971
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 250 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30FDAB "Neuropoisons: Their Pathophysiological Actions, 1971-1974," Simpson,
   L.L., and D.R. Curtis, eds., New York, Plenum Pub. Corp., 1974
   Volume(issue)/page/year: 1,21,1971
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30FDAB "Neuropoisons: Their Pathophysiological Actions, 1971-1974," Simpson,
   L.L., and D.R. Curtis, eds., New York, Plenum Pub. Corp., 1974
   Volume(issue)/page/year: 1,21,1971
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30FDAB "Neuropoisons: Their Pathophysiological Actions, 1971-1974," Simpson,
   L.L., and D.R. Curtis, eds., New York, Plenum Pub. Corp., 1974
   Volume(issue)/page/year: 1,21,1971
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 600 ng/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Cardiac - other changes
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   QJEHAA Quarterly Journal of Experimental Physiology (1957).  (London, UK)
   V.1-27, 1920-38.  For publisher information, see QJEPAY.
   Volume(issue)/page/year: 20,7,1930
 
                            *** END OF RECORD ***