*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YX3992600
CHEMICAL NAME : Venom, snake, Naja nigricollis
LAST UPDATED : 199109
DATA ITEMS CITED : 13
COMPOUND DESCRIPTOR : Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* Naja nigricollis venom
* N. nigricollis venom
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30FDAB "Neuropoisons: Their Pathophysiological Actions, 1971-1974," Simpson,
L.L., and D.R. Curtis, eds., New York, Plenum Pub. Corp., 1974
Volume(issue)/page/year: 1,21,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 352 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 18,384,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HSZPAZ Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie. (Walter de
Gruyter, Inc., 200 Saw Mill River Rd., Hawthorne, NY 10532) V.21- 1895/96-
Volume(issue)/page/year: 297,104,1954
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 30 ug/kg
TOXIC EFFECTS :
Autonomic Nervous System - ganglion blocker
Autonomic Nervous System - parasympatholytic
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 20,111,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 440 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 13,475,1975
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 10,151,1972
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30FDAB "Neuropoisons: Their Pathophysiological Actions, 1971-1974," Simpson,
L.L., and D.R. Curtis, eds., New York, Plenum Pub. Corp., 1974
Volume(issue)/page/year: 1,21,1971
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 2,5,1964
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 350 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
Volume(issue)/page/year: 251,1822,1960
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30FDAB "Neuropoisons: Their Pathophysiological Actions, 1971-1974," Simpson,
L.L., and D.R. Curtis, eds., New York, Plenum Pub. Corp., 1974
Volume(issue)/page/year: 1,21,1971
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 330 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30FDAB "Neuropoisons: Their Pathophysiological Actions, 1971-1974," Simpson,
L.L., and D.R. Curtis, eds., New York, Plenum Pub. Corp., 1974
Volume(issue)/page/year: 1,21,1971
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 1250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30FDAB "Neuropoisons: Their Pathophysiological Actions, 1971-1974," Simpson,
L.L., and D.R. Curtis, eds., New York, Plenum Pub. Corp., 1974
Volume(issue)/page/year: 1,21,1971
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE : 10 ug/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 13,475,1975
*** END OF RECORD ***