*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YX3989300
CHEMICAL NAME           : Venom, snake, Laticauda semifasciata
LAST UPDATED            : 199109
DATA ITEMS CITED        : 11
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Laticauda semifasciata venom
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85EGD4 "Toxins: Animal, Plant and Microbial; Proceedings of the
   International Symposium," Rosenberg, P., ed., New York, Pergamon Press Inc.,
   1978  Volume(issue)/page/year: -,426,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 211 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TIHHAH Tai-wan I Hsueh Hui Tsa Chih.  Journal of the Formosan Medical
   Association.  (Tai-wan I Hsueh Hui, 1, Sect. 1 Jen-ai Road, Taipei, Taiwan)
   V.45-    1946-  Volume(issue)/page/year: 58,182,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:
   99,624,1966
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 10 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   PVMWE2 Poisonous and Venomous Marine Animals of the World.  (U.S. Govt.
   Printing Office, Washington, DC)  Volume(issue)/page/year: 3,974,1970
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 100 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   PVMWE2 Poisonous and Venomous Marine Animals of the World.  (U.S. Govt.
   Printing Office, Washington, DC)  Volume(issue)/page/year: 3,974,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 49500 ng/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TIHHAH Tai-wan I Hsueh Hui Tsa Chih.  Journal of the Formosan Medical
   Association.  (Tai-wan I Hsueh Hui, 1, Sect. 1 Jen-ai Road, Taipei, Taiwan)
   V.45-    1946-  Volume(issue)/page/year: 58,182,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 48600 ng/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TIHHAH Tai-wan I Hsueh Hui Tsa Chih.  Journal of the Formosan Medical
   Association.  (Tai-wan I Hsueh Hui, 1, Sect. 1 Jen-ai Road, Taipei, Taiwan)
   V.45-    1946-  Volume(issue)/page/year: 58,182,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 89700 ng/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   TIHHAH Tai-wan I Hsueh Hui Tsa Chih.  Journal of the Formosan Medical
   Association.  (Tai-wan I Hsueh Hui, 1, Sect. 1 Jen-ai Road, Taipei, Taiwan)
   V.45-    1946-  Volume(issue)/page/year: 58,182,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 63100 ng/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   TIHHAH Tai-wan I Hsueh Hui Tsa Chih.  Journal of the Formosan Medical
   Association.  (Tai-wan I Hsueh Hui, 1, Sect. 1 Jen-ai Road, Taipei, Taiwan)
   V.45-    1946-  Volume(issue)/page/year: 58,182,1959
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TIHHAH Tai-wan I Hsueh Hui Tsa Chih.  Journal of the Formosan Medical
   Association.  (Tai-wan I Hsueh Hui, 1, Sect. 1 Jen-ai Road, Taipei, Taiwan)
   V.45-    1946-  Volume(issue)/page/year: 58,182,1959

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   KOBUA3 Kobunshi.  High Polymers.  (Kobunshi Gakkai, 5-12-8, Ginza, Chuo-Ku,
   Tokyo 104, Japan) V.1-    1952-  Volume(issue)/page/year: 23,728,1974

 
                            *** END OF RECORD ***