*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YX3970800
CHEMICAL NAME           : Venom, snake, Agkistrodon rhodostoma
LAST UPDATED            : 199109
DATA ITEMS CITED        : 8
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Agkistrodon rhodostoma venom
   * Malayan pit viper venom
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JCINAO Journal of Clinical Investigation.  (Rockefeller Univ. Press, 1230
   York Ave., New York, NY 10021)  V.1-    1924-  Volume(issue)/page/year:
   45,1202,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4977 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 9,131,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16100 ug/kg
TOXIC EFFECTS :
   Blood - hemorrhage
REFERENCE :
   19DDA6 "Animal Toxins, a Collection of Papers Presented at the International
   Symposium on Animal Toxins, 1st, 1966," Russell, F.E., and P.R. Saunders,
   eds., New York, Pergamon Press Inc., 1967 Volume(issue)/page/year:
   -,323,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2820 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 7,239,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 900 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory stimulation
   Blood - change in clotting factors
REFERENCE :
   19DDA6 "Animal Toxins, a Collection of Papers Presented at the International
   Symposium on Animal Toxins, 1st, 1966," Russell, F.E., and P.R. Saunders,
   eds., New York, Pergamon Press Inc., 1967 Volume(issue)/page/year:
   -,323,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1900 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   19DDA6 "Animal Toxins, a Collection of Papers Presented at the International
   Symposium on Animal Toxins, 1st, 1966," Russell, F.E., and P.R. Saunders,
   eds., New York, Pergamon Press Inc., 1967 Volume(issue)/page/year:
   1,323,1967
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 13 ug/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Blood - other changes
REFERENCE :
   JCINAO Journal of Clinical Investigation.  (Rockefeller Univ. Press, 1230
   York Ave., New York, NY 10021)  V.1-    1924-  Volume(issue)/page/year:
   45,1202,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 23,614,1985
 
                            *** END OF RECORD ***