*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YW1925000
CHEMICAL NAME : Vanadium, oxysulfato-
CAS REGISTRY NUMBER : 27774-13-6
LAST UPDATED : 199701
DATA ITEMS CITED : 37
MOLECULAR FORMULA : O5-S-V
MOLECULAR WEIGHT : 163.00
WISWESSER LINE NOTATION : VA S-O5
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* C.I. 77940
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 140 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AJSNAO American Journal of Syphilis and Neurology. (St. Louis, MO) V.1-19,
1917-35. For publisher information, see AJSGA3. Volume(issue)/page/year:
1,347,1917
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 44988 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
Volume(issue)/page/year: 256,1043,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
UK) V.30- 1967- Volume(issue)/page/year: 34,135,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 4450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-
1990- Volume(issue)/page/year: 1,712,1992
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 16 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AJSNAO American Journal of Syphilis and Neurology. (St. Louis, MO) V.1-19,
1917-35. For publisher information, see AJSGA3. Volume(issue)/page/year:
1,347,1917
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 31 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AJSNAO American Journal of Syphilis and Neurology. (St. Louis, MO) V.1-19,
1917-35. For publisher information, see AJSGA3. Volume(issue)/page/year:
1,347,1917
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 43198 ug/kg/6W-I
TOXIC EFFECTS :
Gastrointestinal - malabsorption
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 37,899,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 864 mg/kg/12W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Nutritional and Gross Metabolic - changes in metals, not otherwise specified
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 40,309,1988
** MUTATION DATA **
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 6 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 1,21,1986
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 4 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 1,21,1986
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 319,205,1993
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 40 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 319,205,1993
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 319,205,1993
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,53,1995
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,53,1995
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 6 mg/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 50,327,1990
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 19200 ug/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 50,327,1990
*** REVIEWS ***
TOXICOLOGY REVIEW
FRMBAZ Farmacia (Bucharest). (Rompresfilatelia, POB 12-201, Bucharest,
Romania) V.1- 1953- Volume(issue)/page/year: 21,325,1973
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: V,46,1974
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg(V2O5)/m3 JAN 1993
OEL-BELGIUM:TWA 0.05 mg(V2O5)/m3 JAN 1993
OEL-DENMARK:TWA 0.03 mg(V2O5)/m3 JAN 1993
OEL-FINLAND:TWA 0.5 mg(V2O5)/m3 JAN 1993
OEL-FRANCE:TWA 0.05 mg(V2O5)/m3 JAN 1993
OEL-GERMANY:TWA 0.05 mg(V2O5)/m3 JAN 1993
OEL-HUNGARY:TWA 0.05 mg(V2O5)/m3;STEL 0.1 mg(V205)/m3 JAN 1993
OEL-JAPAN:TWA 0.5 mg(V2O5)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg(V2O5)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.25 mg(V205)/m3 JAN 1993
OEL-POLAND:TWA 0.5 mg(V2O5)/m3 JAN 1993
OEL-SWEDEN:STEL 0.05 mg(V2O5)/m3 JAN 1993
OEL-SWEDEN:TWA 0.2 mg(V2O5)/m3 (dust) JAN 1993
OEL-SWITZERLAND:TWA 0.05 mg(V2O5)/m3;STEL 0.25 mg(V2O5)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(V2O5)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg(V2O5)/m3 (dust) JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg(V2O5)/m3 JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***