*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YU7355000
CHEMICAL NAME           : Uridine, 5-(2-bromovinyl)-2'-deoxy-, (E)-
CAS REGISTRY NUMBER     : 69304-47-8
LAST UPDATED            : 199509
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C11-H13-Br-N2-O5
MOLECULAR WEIGHT        : 333.17
WISWESSER LINE NOTATION : T6NVMVJ E1U1E A- ET5OTJ B1Q CQ
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Brivudine
   * (E)-5-(2-Bromovinyl)-deoxyuridine
   * trans-5-(2-Bromovinyl)-2'-deoxyuridine
   * BVDU
   * Uridine, 5-(2-bromoethenyl)-2'-deoxy-, (E)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1420 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHATDV Chemioterapia Antimicrobica.  (Florence, Italy)  V.1-5, 1978-81(?).
   Volume(issue)/page/year: 4,70,1981
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 10920 mg/kg/52W-I
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Liver - other changes
   Nutritional and Gross Metabolic - changes in chlorine
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   11,143,1988
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 24 mg/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 24,803,1983
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 mg/L
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   283,817,1981
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 50 mg/L
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   283,817,1981
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 4 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 267,125,1992
 
                            *** END OF RECORD ***