*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YT9690000
CHEMICAL NAME : Urea, 1-nitrophenyl-3-(3-pyridylmethyl)-
CAS REGISTRY NUMBER : 53558-25-1
OTHER CAS REGISTRY NOS. : 64060-28-2
BEILSTEIN REFERENCE NO. : 0490322
REFERENCE : 5-22-09-00313 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C13-H12-N4-O3
MOLECULAR WEIGHT : 272.29
WISWESSER LINE NOTATION : T6NJ C1MVMR DNW
COMPOUND DESCRIPTOR : Agricultural Chemical
Human
SYNONYMS/TRADE NAMES :
* DLP-87
* DLP 787
* N-(4-Nitrophenyl)-N'-(3-pyridinylmethyl)urea
* N-3-Pyridylmethyl-N'-p-nitrophenylurea
* 1-(3-Pyridylmethyl)-3-(4-nitrophenyl)urea
* Pyriminil
* Pyriminyl
* Pyrinuron
* RH-787
* Vacor
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 31 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Vascular - BP lowering not characterized in autonomic section
Endocrine - diabetes mellitus
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 18,441,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 22 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
Kidney, Ureter, Bladder - other changes
Endocrine - diabetes mellitus
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 18,441,1981
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 22286 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - hallucinations, distorted perceptions
Endocrine - hyperglycemia
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year:
302,73,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6200 ug/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1901- Volume(issue)/page/year: 80,401,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) Beginning history not known. Volume(issue)/page/year: 13,220,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 56500 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Sense Organs and Special Senses (Eye) - hemorrhage
REFERENCE :
ESDBAK Eisei Dobutsu. Sanitary Zoology. (Nippon Eisei Dobutsu Gakkai, c/o
Kokuritsu Yobo Eisei Kenkyusho Eisei Konchubo, 2-10-35 Kami-osaki,
Shinagawa-ku, Tokyo 141, Japan) V.1- 1950- Volume(issue)/page/year:
28,349,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 17200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) Beginning history not known. Volume(issue)/page/year: 13,220,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SHBOAO Shokubutsu Boeki. (Nippon Shokubutsu Boeki Kyokai, 43-11, Komagome
1-chome, Toshima-Ku, Tokyo, Japan) V.1- 1947- Volume(issue)/page/year:
32,530,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C319,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 760 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Behavioral - muscle contraction or spasticity
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 20,216,1988
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 24500 mg/kg/28D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 20,216,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***