*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YT8850000
CHEMICAL NAME           : Urea, 1-(1-methyl-2-pyrrolidinylidene)-3-(2,6-xylyl)-
CAS REGISTRY NUMBER     : 50528-97-7
BEILSTEIN REFERENCE NO. : 0406212
REFERENCE               : 5-22-08-00197 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C14-H19-N3-O
MOLECULAR WEIGHT        : 245.36
WISWESSER LINE NOTATION : T5NYTJ A1 BUNVMR B1 F1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N-(2,6-Dimethylphenyl)-N'-(1-methyl-2-pyrrolidinylidene)urea
   * McN-3113
   * 1-(1-Methyl-2-pyrrolidinylidene)-3-(2,6-xylyl)urea
   * Urea, N-(2,6-dimethylphenyl)-N'-(1-methyl-2-pyrrolidinylidene)-
   * Xilobam
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 830 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - rigidity (including catalepsy)
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 233,326,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - rigidity (including catalepsy)
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 233,326,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 21,1044,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - rigidity (including catalepsy)
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 233,326,1978
 
                            *** END OF RECORD ***