*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YS9100000
CHEMICAL NAME : Urea, 3-(3,4-dichlorophenyl)-1-methoxy-1-methyl-
CAS REGISTRY NUMBER : 330-55-2
BEILSTEIN REFERENCE NO. : 2128725
LAST UPDATED : 199710
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C9-H10-Cl2-N2-O2
MOLECULAR WEIGHT : 249.11
WISWESSER LINE NOTATION : GR BG DMVN1&O1
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
SYNONYMS/TRADE NAMES :
* Afalon
* Afalon inuron
* Aphalon
* Cephalon
* 3-(3,4-Dichloor-fenyl)-1-methoxy-1-methylureum
* 3-(3,4-Dichloro-fenil)-1-metossi-1-metil-urea
* 3-(3,4-Dichlorophenyl)-1-methoxymethylurea
* 3-(3,4-Dichlorophenyl)-1-methoxy-1-methylurea
* N'-(3,4-Dichlorophenyl)-N-methoxy-N-methylurea
* 1-(3,4-Dichlorophenyl)3-methoxy-3-methyluree
* N-(3,4-Dichlorophenyl)-N'-methyl-N'-methoxyurea
* 3-(3,4-Dichlor-phenyl)-1-methoxy-1-methyl-harnstoff
* 3-(4,5-Dichlorphenyl)-1-methoxy-1-methylharnstoff
* Du Pont 326
* Dupont herbicide 326
* N-(3,4-Dwuchlorofenylo)N'-metoksy-N'-metylomocznik
* Garnitan
* Herbicide 326
* HOE 2810
* Laroks
* Linex 4L
* Linorox
* Linurex
* Linuron
* Linuron
* Lorex
* Lorox
* Lorox linuron weed killer
* Methoxydiuron
* 1-Methoxy-1-methyl-3-(3,4-dichlorophenyl)urea
* Sarclex
* Scarclex
* Sinuron
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1146 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
7,299,1986
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 48 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,48,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
7,299,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 36,387,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,317,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year:
A248,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,520,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 3765 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 58(7),63,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 gm/kg/60D-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - catalases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
REFERENCE :
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068
Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 21,145,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1070 mg/kg/31W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 40(7),46,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 gm/kg/10D-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 58(7),63,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 7500 mg/kg/30D-I
TOXIC EFFECTS :
Behavioral - muscle weakness
Cardiac - EKG changes not diagnostic of specified effects
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 58(7),63,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : 1750 mg/kg/7D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Related to Chronic Data - death
REFERENCE :
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 58(7),63,1982
** MUTATION DATA **
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 4500 mg/kg/2W (Intermittent)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 390,207,1997
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 500 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,353,1978
*** REVIEWS ***
TOXICOLOGY REVIEW
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***