*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YS7800000
CHEMICAL NAME           : Urea, 1-cyclohexyl-3-(p-tolylsulfonyl)-
CAS REGISTRY NUMBER     : 664-95-9
BEILSTEIN REFERENCE NO. : 1995860
REFERENCE               : 4-12-00-00057 (Beilstein Handbook Reference)
LAST UPDATED            : 199706
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C14-H20-N2-O3-S
MOLECULAR WEIGHT        : 296.42
WISWESSER LINE NOTATION : L6TJ AMVMSWR D1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Agliral
   * Benzenesulfonamide, N-((cyclohexylamino)carbonyl)-4-methyl-
   * 1-Cicloesil-3-p-tolilsolfonilurea
   * Cychloral
   * Cyclamid
   * Cyclamide
   * 1-Cyclohexyl-3-p-toluenesulfonylurea
   * 1-Cyclohexyl-3-p-tolylsulfonylurea
   * Diaboral
   * Glicosil
   * Glycyclamide
   * K 386
   * N-(4-Methylbenzenesulfonyl)-N'-cyclohexylurea
   * Tolcyclamide
   * Tolhexamide
   * 1-(p-Tolylsulfonyl)-3-cyclohexylurea
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 870 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 12,268,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,280,1970
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 800 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 28,616,1965
 
                            *** END OF RECORD ***