*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YS4981500
CHEMICAL NAME           : Urea, 1-(2-chloroethyl)-3-(4-hydroxybutyl)-1-nitroso-
CAS REGISTRY NUMBER     : 60784-48-7
LAST UPDATED            : 199109
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C7-H14-Cl-N3
MOLECULAR WEIGHT        : 175.69
WISWESSER LINE NOTATION : Q4MVNNO&2G
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 1-(2-Chloroethyl)-3-(4-hydroxybutyl)-1-nitrosourea
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 13,937,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1 mmol/L/16H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,45,1977

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion

 
                            *** END OF RECORD ***