*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YS4906350
CHEMICAL NAME           : Urea,
                          N-(2-chloroethyl)-N'-(2,6-dihydroxycyclohexyl)-N-nitr
                          oso-, (1-alpha,2-beta,6-beta)-
CAS REGISTRY NUMBER     : 58484-17-6
LAST UPDATED            : 198610
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C9-H16-Cl-N3-O4
MOLECULAR WEIGHT        : 265.73
WISWESSER LINE NOTATION : L6TJ AQ BMVNNO&2G CQ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N-(2-Chloroethyl)-N'-(2,6-dihydroxycyclohexyl)-N-nitrosourea
   * trans-1-(2-Chloroethyl)-3-(2,6-dihydroxycyclohexyl)-1-nitrosourea
   * 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)-1,3-cyclohexanediol
   * trans,trans-2,6-Dihydroxy-ccnu
   * DONU
   * NSC 264395
   * Urea, 1-(2-chloroethyl)-3-(2,6-dihydroxycyclohexyl)-1-nitroso-, (E)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 33010 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 11500 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year: 6,25,1981
 
                            *** END OF RECORD ***