*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YR8449000
CHEMICAL NAME : Urea,
N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chlo
roethyl)-N-nitroso-
CAS REGISTRY NUMBER : 42471-28-3
BEILSTEIN REFERENCE NO. : 0685903
REFERENCE : 5-25-12-00136 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C9-H13-Cl-N6-O2
MOLECULAR WEIGHT : 272.73
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 3-(4-Amino-2-methyl-5-pyrimidinyl)methyl-1-(2-chloroethyl)-1-nitrosourea
* Nimustine
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE : 3 mg/kg
SEX/DURATION : multigeneration
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
YSKODB Yakubutsu, Seishin, Kodo. Japanese Journal of Psychopharmacology.
(Nippon Shinkei, Seishin Yakuri Gakkai, 1433 Nogawa, Miyamae-ku, Kawasaki,
213, Japan) V.1- 1981- Volume(issue)/page/year: 11,438,1991
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 75 ug/plate
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 44,96,1985
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 75 ug/plate
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 44,96,1985
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 100 ug/plate
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 44,96,1985
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 50 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
47,1361,1987
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 umol/L
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For
publisher information, see JNCIEQ. Volume(issue)/page/year: 69,505,1985
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 8 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
47,1361,1987
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,95,1985
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 2 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,95,1985
*** END OF RECORD ***