*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YR9050000
CHEMICAL NAME           : Urea, 1-(2'-benzothiazolyl)-3-methyl-3-nitroso-
CAS REGISTRY NUMBER     : 51542-33-7
LAST UPDATED            : 199106
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C9-H8-N4-O-S
MOLECULAR WEIGHT        : 220.27
WISWESSER LINE NOTATION : T56 BN DSJ CMVN1&NW
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * N-(2-Benzothiazolyl)-N'-methyl-N'-nitrosourea
   * N-Methyl-N-nitroso-N'-(2-benzothiazolyl)-harnstoff
   * N-Methyl-N-nitroso-N'-(2-benzothiazolyl)-urea
   * N-Nitrosobenzthiazuron
   * N-Nitroso-N-methyl-N'-(2-benzothiazolyl)urea
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Kidney, Ureter, Bladder - other changes
   Blood - hemorrhage
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 81,217,1974
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1156 mg/kg/64W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   IARCCD IARC Scientific Publications.  (Geneva, Switzerland)  No.1-26,
   1971-78.  For publisher information, see IAPUDO.  Volume(issue)/page/year:
   14,429,1976
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 81,217,1974
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 429 mg/kg/86W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   IARCCD IARC Scientific Publications.  (Geneva, Switzerland)  No.1-26,
   1971-78.  For publisher information, see IAPUDO.  Volume(issue)/page/year:
   14,429,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1060 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 22,121,1974

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; S cerevisiae
   gene conversion

 
                            *** END OF RECORD ***