*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YR7000000
CHEMICAL NAME           : Urea, 3-acetyl-1-methyl-1-nitroso-
CAS REGISTRY NUMBER     : 28895-91-2
BEILSTEIN REFERENCE NO. : 1770935
REFERENCE               : 4-04-00-03385 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C4-H7-N3-O3
MOLECULAR WEIGHT        : 145.14
WISWESSER LINE NOTATION : ONN1&VMV1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acetyl-methyl-nitroso-harnstoff
   * Acetylmethylnitrosourea
   * N'-Acetyl-methylnitrosourea
   * N-Methyl-N-nitroso-N'-acetylurea
   * 1-Methyl-1-nitrosoacetylurea
   * Urea, 1-methyl-1-nitrosoacetyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   XENOBH Xenobiotica.  (Taylor & Francis Ltd., 4 John St., London WC1N 2ET,
   UK)  V.1-    1971-  Volume(issue)/page/year: 3,271,1973
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 468 mg/kg/47W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Brain and Coverings - tumors
   Gastrointestinal - tumors
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   74,23,1970
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 740 mg/kg/74W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   XENOBH Xenobiotica.  (Taylor & Francis Ltd., 4 John St., London WC1N 2ET,
   UK)  V.1-    1971-  Volume(issue)/page/year: 3,271,1973
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 540 mg/kg/54W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Brain and Coverings - tumors
   Gastrointestinal - tumors
REFERENCE :
   PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
   Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
   Tokyo 113, Japan)  1st-    1971-  Volume(issue)/page/year: 2,73,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 500 mg/L/20H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,337,1977
 
                            *** END OF RECORD ***