*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YQ9100000
CHEMICAL NAME : Uracil, 5-bromo-3-sec-butyl-6-methyl-
CAS REGISTRY NUMBER : 314-40-9
BEILSTEIN REFERENCE NO. : 0647896
REFERENCE : 5-24-07-00040 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 34
MOLECULAR FORMULA : C9-H13-Br-N2-O2
MOLECULAR WEIGHT : 261.15
WISWESSER LINE NOTATION : T6MVNVJ CY2&1 EE F1
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Borea
* Bromacil
* Bromax
* Bromazil
* 5-Bromo-3-sec-butyl-6-methyluracil
* 5-Bromo-6-methyl-3-(1-methylpropyl)-2,4(1H,3H)-pyrimidinedione
* 5-Bromo-6-methyl-3-(1-methylpropyl)uracil
* 3-sek.Butyl-5-brom-6-methyluracil
* Cynogan
* Du Pont herbicide 976
* Eerex Granular Weed Killer
* Eerex Water Soluble Concentrate Weed Killer
* Herbicide 976
* Hyvarex
* Hyvar X
* Hyvar X-L
* Hyvar X bromacil
* Hyvar X Weed Killer
* Hyvar X-WS
* Krovar II
* Nalkil
* Urox B
* Urox B water soluble concentrate weed killer
* Urox-HX
* Urox HX granular weed killer
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 641 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
7,299,1986
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >4800 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,93,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
7,299,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3040 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave.,
New York, NY 10016) V.B11- 1976- Volume(issue)/page/year: 15,867,1980
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
34,189,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,93,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10350 mg/kg/2W-I
TOXIC EFFECTS :
Behavioral - ataxia
Gastrointestinal - changes in structure or function of salivary glands
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
34,189,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 45625 mg/kg/2Y-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
34,189,1975
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 38 mg/m3/2H
SEX/DURATION : female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB277-077
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 2000 ppm
REFERENCE :
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave.,
New York, NY 10016) V.B11- 1976- Volume(issue)/page/year: 15,867,1980
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Mold - Neurospora crassa
DOSE/DURATION : 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 167,35,1986
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 750 mg/L
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-138973
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 10 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 ppm (10 mg/m3) JAN 1993
OEL-BELGIUM:TWA 1 ppm (11 mg/m3) JAN 1993
OEL-DENMARK:TWA 5 mg/m3 JAN 1993
OEL-FINLAND:TWA 1 ppm (10 mg/m3);STEL 3 ppm (30 mg/m3) JAN 1993
OEL-FRANCE:TWA 1 ppm (10 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 1 ppm (10 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 1 ppm (10 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1 ppm (10 mg/m3);STEL 2 ppm (20 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BROMACIL-air:10H TWA 1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80830
No. of Facilities: 362 (estimated)
No. of Industries: 11
No. of Occupations: 5
No. of Employees: 1905 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80830
No. of Facilities: 755 (estimated)
No. of Industries: 7
No. of Occupations: 6
No. of Employees: 4372 (estimated)
No. of Female Employees: 63 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; E coli polA
without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP
reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***