*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YQ9000000
CHEMICAL NAME           : Uracil, 5-(bis-(2-chloroethyl)amino)-6-methyl-
CAS REGISTRY NUMBER     : 520-09-2
LAST UPDATED            : 199109
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C9-H13-Cl2-N3-O2
MOLECULAR WEIGHT        : 266.15
WISWESSER LINE NOTATION : T6MVMVJ EN2G2G F1
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 5-(Bis(2-chloroethyl)amino)-6-methyluracil
   * 5-(Bis-(2-cloroetil)-amino)-6-metiluracile
   * Chloroethylaminouracil
   * 2,6-Dihydroxy-4-methyl-5-bis(2-chloroethyl)aminopyrimidine
   * Dopan
   * Dopane
   * Elderfield pyrimidine mustard
   * ENT 50698
   * 4-Methyl-5-(bis(beta-chloroethyl)amino)uracil
   * 6-Methyl-5-(bis(2-chloroethyl)amino)uracil
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   101,630,1962
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 34,83,1971
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   TSITAQ Tsitologiya.  Cytology.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
   USSR)  V.1-    1959-  Volume(issue)/page/year: 15,1505,1973
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 2 mg/L
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 22,105,1975
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 2 mg/L
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 22,105,1975
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Primate - monkey Kidney
DOSE/DURATION           : 100 mg/L
REFERENCE :
   TSITAQ Tsitologiya.  Cytology.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
   USSR)  V.1-    1959-  Volume(issue)/page/year: 15,1505,1973
 
                            *** END OF RECORD ***