*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YM3735000
CHEMICAL NAME           : 1-alpha-H,5-alpha-H-Tropanium,
                          3-alpha-hydroxy-8-methyl-, bromide,
                          xanthene-9-carboxylate
CAS REGISTRY NUMBER     : 4047-34-1
LAST UPDATED            : 198709
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C23-H26-N-O3.Br
MOLECULAR WEIGHT        : 444.41
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 8-Azoniabicyclo(3.2.1)octane,  
   8,8-dimethyl-3-((9H-xanthen-9-ylcarbonyl)oxy)-, bromide, endo-
   * Dexotropine
   * Gastrixon
   * Gastrixone
   * 3-alpha-Hydroxy-8-methyl-1-alpha-H,5-alpha-H-tropanium bromide  
   xanthene-9-carboxylate
   * 8-Methyltropinium bromide xanthene-9-carboxylate
   * N-640
   * Trantelinium bromide
   * Tranthelinium bromide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 658 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,444,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 326 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,444,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4790 ug/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,444,1961
 
                            *** END OF RECORD ***