*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YM6105000
CHEMICAL NAME           : 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, (+-)-tropate
                          (ester), 8-oxide
CAS REGISTRY NUMBER     : 4438-22-6
LAST UPDATED            : 198708
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C17-H23-N-O4
MOLECULAR WEIGHT        : 305.41
SYNONYMS/TRADE NAMES :
   * Aminoxytropine tropate
   * Atropine oxide
   * Atropine N-oxide
   * Genatropin
   * Genatropine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RDMU** "Vergleichende Untersuchungen uber Genatropin und Atropin,
   Dissertation," Rathscheck, U., Pharmakologischen Institut der Westfalichen
   Wilhelms-Universitat Muenster/Westf., Fed. Rep. Ger., 1934
   Volume(issue)/page/year: -,-,1934
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme
   Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
    Volume(issue)/page/year: -,513,1948
 
                            *** END OF RECORD ***