*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YE2465000
CHEMICAL NAME           : Triethylamine, 2-thymyloxy-, hydrochloride
CAS REGISTRY NUMBER     : 75352-37-3
LAST UPDATED            : 199512
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C16-H27-N-O.Cl-H
MOLECULAR WEIGHT        : 285.90
WISWESSER LINE NOTATION : 2N2&2OR C1 FY1&1 &GH
COMPOUND DESCRIPTOR     : Human
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * 2-Isopropyl-5-methylphenoxyethyldiethylamine hydrochloride
   * beta-Thymoxyethyl diethylamine hydrochloride
   * 2-Thymyloxytriethylamine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 ug
REFERENCE :
   AIPAAV Annales de l'Institut Pasteur (Paris).  (Paris, France)  V.1-123,
   1887-1972.  For publisher information, see ANMBCM. Volume(issue)/page/year:
   63,485,1939
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 21 ug/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - dyspnea
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   AIPAAV Annales de l'Institut Pasteur (Paris).  (Paris, France)  V.1-123,
   1887-1972.  For publisher information, see ANMBCM. Volume(issue)/page/year:
   63,485,1939
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AIPAAV Annales de l'Institut Pasteur (Paris).  (Paris, France)  V.1-123,
   1887-1972.  For publisher information, see ANMBCM. Volume(issue)/page/year:
   63,485,1939
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#11949
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AIPAAV Annales de l'Institut Pasteur (Paris).  (Paris, France)  V.1-123,
   1887-1972.  For publisher information, see ANMBCM. Volume(issue)/page/year:
   63,485,1939
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AIPAAV Annales de l'Institut Pasteur (Paris).  (Paris, France)  V.1-123,
   1887-1972.  For publisher information, see ANMBCM. Volume(issue)/page/year:
   63,485,1939
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AIPAAV Annales de l'Institut Pasteur (Paris).  (Paris, France)  V.1-123,
   1887-1972.  For publisher information, see ANMBCM. Volume(issue)/page/year:
   63,485,1939
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AIPAAV Annales de l'Institut Pasteur (Paris).  (Paris, France)  V.1-123,
   1887-1972.  For publisher information, see ANMBCM. Volume(issue)/page/year:
   63,485,1939
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 13,326,1948
 
                            *** END OF RECORD ***