*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : YE0925000 CHEMICAL NAME : Triethylamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)-, citrate, (E)- CAS REGISTRY NUMBER : 7599-79-3 LAST UPDATED : 199801 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C26-H28-Cl-N-O.C6-H8-O7 MOLECULAR WEIGHT : 598.14 WISWESSER LINE NOTATION : GYR&UYR&R DO2N2&2 &QV1XQVQ&1VQ -T COMPOUND DESCRIPTOR : Reproductive Effector Human SYNONYMS/TRADE NAMES : * trans-Clomifene citrate * trans-Clomiphene citrate *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 73500 ug/kg/3W-I TOXIC EFFECTS : Behavioral - wakefulness Behavioral - toxic psychosis REFERENCE : AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 154,1169,1997 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 10 mg/kg/2W-I TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis Behavioral - irritability REFERENCE : AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 154,1169,1997 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 30 mg/kg SEX/DURATION : male 60 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,23,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rabbit DOSE : 90 mg/kg SEX/DURATION : female 21-26 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 23,339,1972 *** END OF RECORD ***