*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YD0165000
CHEMICAL NAME : Trichothec-9-en-8-one,
12,13-epoxy-3,4,7,15-tetrahydroxy-,
(3-alpha,4-beta,7-alpha)-
CAS REGISTRY NUMBER : 23282-20-4
BEILSTEIN REFERENCE NO. : 3625724
LAST UPDATED : 199703
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C15-H20-O7
MOLECULAR WEIGHT : 312.35
WISWESSER LINE NOTATION : T C665 A AX EV IO FUTJ B1 C1Q DQ F1 KQ LQ A-& BT3OX
CHJ
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Natural Product
Primary Irritant
SYNONYMS/TRADE NAMES :
* 12,13-Epoxy-3,4,7,15-tetrahydroxytrichothec-9-en-8-one
* Nivalenol
* 3-alpha,4-beta,7-alpha,15-Tetrahydroxy-12,13-epoxytrichothec-9-en-8-one
* 3-alpha,4-beta,7-alpha,15-Tetrahydroxyscirp-9-en-8-one
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 3124 ng
REACTION SEVERITY : Mild
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
4,S124,1984
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 19500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin
Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
150, Japan) V.1- 1960- Volume(issue)/page/year: 31,144,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin
Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
150, Japan) V.1- 1960- Volume(issue)/page/year: 31,144,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year:
4,135,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953-
Volume(issue)/page/year: 30,251,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Endocrine - other changes
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
28,2393,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores
of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year:
42,91,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 6300 ug/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from small intestine
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
4,S124,1984
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 42 mg/kg/4W-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
27,585,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 126 mg/kg/12W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
27,585,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 131 mg/kg/26W-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
11,38,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 262 mg/kg/1Y-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Blood - leukopenia
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
11,38,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3500 ug/kg/7D-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
Skin and Appendages - hair
REFERENCE :
JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores
of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year:
40,33,1970
** MUTATION DATA **
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Ascites tumor
DOSE/DURATION : 1 mg/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 24,1032,1968
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 56,397,1993
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,225,1974
TOXICOLOGY REVIEW
NUREA8 Nutrition Reviews. (Springer-Verlag New York, Inc., Service Center,
44 Hartz Way, Secaucus, NJ 07094) V.1- 1942- Volume(issue)/page/year:
31,169,1973
*** END OF RECORD ***