*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XZ5478450
CHEMICAL NAME           : s-Triazolo(5,1-a)isoquinoline,
                          5,6-dihydro-2-(4-biphenylyl)-
CAS REGISTRY NUMBER     : 75318-64-8
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H17-N3
MOLECULAR WEIGHT        : 323.42
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 2-(4-Biphenylyl)-5,6-dihydro-s-traizolo(5,1-a)isoquinoline
   * L 13891
   * (1,2,4)Triazolo(5,1-a)isoquinoline, 2-(1,1'-biphenyl)-4-yl-5,6-dihydro-
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 6-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions.  (Freund
   Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
   V.3-    1980-  Volume(issue)/page/year: 4,237,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 2 mg/kg
SEX/DURATION            : female 4-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions.  (Freund
   Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
   V.3-    1980-  Volume(issue)/page/year: 4,237,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 250 ug/kg
SEX/DURATION            : female 4-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JOPHDQ Journal of Pharmacobio-Dynamics.  (Japan Pub. Trading Co. (USA), 1255
   Howard St., San Francisco, CA 94103)  V.1-    1978- Volume(issue)/page/year:
   5,55,1982
 
                            *** END OF RECORD ***