*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XZ5478400
CHEMICAL NAME : s-Triazolo(5,1-a)isoquinoline, 2-(p-chlorophenyl)-
CAS REGISTRY NUMBER : 66535-86-2
BEILSTEIN REFERENCE NO. : 0535459
LAST UPDATED : 199710
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C16-H10-Cl-N3
MOLECULAR WEIGHT : 279.74
COMPOUND DESCRIPTOR : Reproductive Effector
SYNONYMS/TRADE NAMES :
* Canocenta
* 2-(p-Chlorophenyl)-s-triazolo(5,1-a)isoquinoline
* 2-(4-Chlorophenyl)-(1,2,4)triazolo(5,1-a)isoquinoline
* DL 717
* DL 717IT
* L 12717
* Lotrifen
* Privaprol
* (1,2,4)Triazolo(5,1-a)isoquinoline, 2-(4-chlorophenyl)-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
23,75,1987
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
23,75,1987
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 4500 ug/kg
SEX/DURATION : female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund
Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
V.3- 1980- Volume(issue)/page/year: 4,237,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 2500 ug/kg
SEX/DURATION : female 4-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
23,75,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE : 500 ug/kg
SEX/DURATION : female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JAPRAN Journal of Small Animal Practice. (Biochemical Soc. Book Depot, POB
32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 23,295,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Mammal - dog
DOSE : 500 ug/kg
SEX/DURATION : female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund
Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
V.3- 1980- Volume(issue)/page/year: 4,237,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE : 40 mg/kg
SEX/DURATION : female 4-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund
Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
V.3- 1980- Volume(issue)/page/year: 4,237,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE : 40 mg/kg
SEX/DURATION : female 4-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255
Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year:
5,55,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - hamster
DOSE : 70 ug/kg
SEX/DURATION : female 4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund
Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
V.3- 1980- Volume(issue)/page/year: 4,237,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - hamster
DOSE : 125 ug/kg
SEX/DURATION : female 4-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255
Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year:
5,55,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravaginal
SPECIES OBSERVED : Rodent - hamster
DOSE : 15 mg/kg
SEX/DURATION : female 4-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund
Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
V.3- 1980- Volume(issue)/page/year: 4,237,1982
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***