*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XZ5478300
CHEMICAL NAME           : s-Triazolo(5,1-a)isoquinoline, 2-(4-biphenylyl)-
CAS REGISTRY NUMBER     : 75318-62-6
BEILSTEIN REFERENCE NO. : 5975029
LAST UPDATED            : 199612
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C22-H15-N3
MOLECULAR WEIGHT        : 321.40
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 2-(1,1'-Biphenyl-4-yl)-s-triazole(5,1-a)isoquinoline
   * 2-(1,1'-Biphenyl-4-yl)-1,2,4-triazole(5,1-a)isoquinoline
   * 2-(4-Biphenylyl)-s-triazolo(5,1-a)isoquinoline
   * L 14105
   * (1,2,4)Triazolo(5,1-a)isoquinoline, 2-(1,1'-biphenyl)-4-yl-
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 6-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JVPTD9 Journal of Veterinary Pharmacology and Therapeutics.  (Blackwell
   Scientific Pub. Ltd., POB 88, Oxford, UK)  V.1-    1978-
   Volume(issue)/page/year: 9,246,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2500 ug/kg
SEX/DURATION            : female 6-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 33,1222,1983
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2500 ug/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JVPTD9 Journal of Veterinary Pharmacology and Therapeutics.  (Blackwell
   Scientific Pub. Ltd., POB 88, Oxford, UK)  V.1-    1978-
   Volume(issue)/page/year: 9,246,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 35 mg/kg
SEX/DURATION            : female 18-24 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JVPTD9 Journal of Veterinary Pharmacology and Therapeutics.  (Blackwell
   Scientific Pub. Ltd., POB 88, Oxford, UK)  V.1-    1978-
   Volume(issue)/page/year: 9,246,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 1 mg/kg
SEX/DURATION            : female 19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JVPTD9 Journal of Veterinary Pharmacology and Therapeutics.  (Blackwell
   Scientific Pub. Ltd., POB 88, Oxford, UK)  V.1-    1978-
   Volume(issue)/page/year: 9,246,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 1250 ug/kg
SEX/DURATION            : female 4-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JVPTD9 Journal of Veterinary Pharmacology and Therapeutics.  (Blackwell
   Scientific Pub. Ltd., POB 88, Oxford, UK)  V.1-    1978-
   Volume(issue)/page/year: 9,246,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 1 mg/kg
SEX/DURATION            : female 4-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JOPHDQ Journal of Pharmacobio-Dynamics.  (Japan Pub. Trading Co. (USA), 1255
   Howard St., San Francisco, CA 94103)  V.1-    1978- Volume(issue)/page/year:
   5,55,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 75 ug/kg
SEX/DURATION            : female 4-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 33,1222,1983
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 80 ug/kg
SEX/DURATION            : female 4-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JOPHDQ Journal of Pharmacobio-Dynamics.  (Japan Pub. Trading Co. (USA), 1255
   Howard St., San Francisco, CA 94103)  V.1-    1978- Volume(issue)/page/year:
   5,55,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 50 ug/kg
SEX/DURATION            : female 4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JVPTD9 Journal of Veterinary Pharmacology and Therapeutics.  (Blackwell
   Scientific Pub. Ltd., POB 88, Oxford, UK)  V.1-    1978-
   Volume(issue)/page/year: 9,246,1986
 
                            *** END OF RECORD ***