*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XZ3012000
CHEMICAL NAME : s-Triazin-2(1H)-one,
4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-
CAS REGISTRY NUMBER : 2353-33-5
BEILSTEIN REFERENCE NO. : 0617982
LAST UPDATED : 199709
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C8-H12-N4-O4
MOLECULAR WEIGHT : 228.24
WISWESSER LINE NOTATION : T6NVN ENJ DZ A- ET5OTJ B1Q CQ
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one
* 5-Azadeoxycytidine
* 5-Aza-2'-deoxycytidine
* 1,3,5-Triazin-2(1H)-one,
4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
37,3684,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 22 mg/kg
TOXIC EFFECTS :
Blood - leukopenia
Blood - thrombocytopenia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 4,373,1981
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 1 mg/kg
SEX/DURATION : female 8-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 112,37,1996
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 300 ug/kg
SEX/DURATION : female 10-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 112,37,1996
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 300 ug/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 112,37,1996
** MUTATION DATA **
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 1 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
46,5511,1986
TYPE OF TEST : DNA damage
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 226,185,1989
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 300 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
48,2440,1988
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 umol/L
REFERENCE :
HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.31- 1976- Volume(issue)/page/year:
71,342,1985
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 20 mg/kg
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 35,112,1980
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 100 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
46,5511,1986
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 4 mg/kg
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
29,2929,1980
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 3 mg/kg
REFERENCE :
CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press
Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929-
Volume(issue)/page/year: 48,3020,1983
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 40 nmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 10,2003,1989
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 1 umol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
697,286,1982
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 5 umol/L
REFERENCE :
EJCAEL European Journal of Cancer. (Pergamon Press, c/o Elsevier Science,
660 White Plains Rd., Tarrytown, NY 10591) V.26-28(2/3), 1990-92. For
publisher information, see EJCTEA Volume(issue)/page/year: 28,362,1992
*** END OF RECORD ***