*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XZ2854400
CHEMICAL NAME           : s-Triazin-2(1H)-one,
                          4-amino-1-beta-D-arabinofuranosyl-
CAS REGISTRY NUMBER     : 65886-71-7
LAST UPDATED            : 199206
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C8-H12-N4-O5
MOLECULAR WEIGHT        : 244.24
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * 4-Amino-1-beta-D-arabinofuranosyl-s-triazin-3(2H)-one
   * Ara-AC
   * 1-beta-D-Arabinofuranosyl-5-azacytosine
   * 5-Azacytosine arabinoside
   * Fazarabine
   * NSC 281272
   * 1,3,5-Triazin-2(1H)-one, 4-amino-1-beta-D-arabinofuranosyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 1557 ug/kg/72H-C
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Blood - agranulocytosis
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 29,194,1988
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   45,3522,1985
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   42,409,1991
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 2 umol/L
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 24,297,1983
 
                            *** END OF RECORD ***