*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XZ1400000
CHEMICAL NAME : s-Triazine, 2,4,6-trichloro-
CAS REGISTRY NUMBER : 108-77-0
BEILSTEIN REFERENCE NO. : 0124246
REFERENCE : 5-26-01-00311 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C3-Cl3-N3
MOLECULAR WEIGHT : 184.41
WISWESSER LINE NOTATION : T6N CN ENJ BG DG FG
COMPOUND DESCRIPTOR : Tumorigen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Chlorotriazine
* Cyanurchloride
* Cyanuric acid chloride
* Cyanuric trichloride
* Cyanuryl chloride
* Kyanurchlorid
* s-Triazine trichloride
* Trichlorocyanidine
* Trichloro-s-triazine
* sym-Trichlorotriazine
* 1,3,5-Trichlorotriazine
* 2,4,6-Trichlorotriazine
* 2,4,6-Trichloro-s-triazine
* 2,4,6-Trichloro-1,3,5-triazine
* syn-Trichlotriazin
* Tricyanogen chloride
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,152,1972
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 50 ug/24H
REACTION SEVERITY : Severe
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,152,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 485 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 12(8),35,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 350 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 12(8),35,1968
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10 mg/m3/2H
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - somnolence (general depressed activity)
Musculoskeletal - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 12(8),35,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4891,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#07336
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2800 mg/kg/28D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - pigmented or nucleated red blood cells
Related to Chronic Data - death
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 12,119,1992
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1880 ug/m3/4H/11W-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 12(8),35,1968
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20 gm/kg/73W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.1- 1955- Volume(issue)/page/year: 12(4),78,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Multiple routes
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 16 gm/kg/73W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.1- 1955- Volume(issue)/page/year: 12(4),78,1966
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4559
No. of Facilities: 20 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 2336 (estimated)
No. of Female Employees: 299 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***