*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XY4390000
CHEMICAL NAME : s-Triazine, 2,4-bis(isopropylamino)-6-(methylthio)-
CAS REGISTRY NUMBER : 7287-19-6
OTHER CAS REGISTRY NOS. : 83653-07-0
BEILSTEIN REFERENCE NO. : 0613575
LAST UPDATED : 199710
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C10-H19-N5-S
MOLECULAR WEIGHT : 241.40
WISWESSER LINE NOTATION : T6N CN ENJ BS1 DMY1&1 FMY1&1
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* 2,4-Bis(isopropylamino)-6-methyl mercapto-s-triazine
* 2,4-Bis(isopropylamino)-6-methylthio-s-triazine
* 2,4-Bis(isopropylamino)-6-methylthio-1,3,5-triazine
* N,N'-Bis(1-methylethyl)-6-methyl-thio-1,3,5-triazine-2,4-diamine
* 2,4-Bis(propylamino)-6-methylthio-1,3,5-triazin
* Caparol
* N,N'-Diisopropyl-6-methylthio-1,3,5-triazine-2,4-diyldiamine
* G 34161
* Gesagard
* Mercazin
* Merkazin
* 2-Methylmercapto-4,6-bis(isopropylamino)-s-triazine
* 2-Methylthio-4,6-bis(isopropylamino)-s-triazine
* Polisin
* Primatol Q
* Promepin
* Promethryn
* Prometrene
* Prometrex
* Prometrin
* Prometryn
* Prometryne
* Selectin
* Selektin
* Sesagard
* s-Triazine, 4,6-bis(isopropylamino)-2-methylmercapto-
* 1,3,5-Triazine-2,4-diamine, N,N'-bis(1-methylethyl)-6-(methylthio)-
* Uvon
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 80 mg
REACTION SEVERITY : Mild
REFERENCE :
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris
Ave., Summit, NJ 07901) Volume(issue)/page/year: -,-,1977
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2100 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 34(3),94,1969
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2430 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year:
A340,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >3100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,711,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2138 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory depression
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 33(2),12,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >3100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C250,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 44(6),81,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14223 mg/kg/7W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in adrenal weight
Blood - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 33(2),12,1968
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 2400 mg/kg
SEX/DURATION : female 18-20 day(s) after conception
lactating female 2-4 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - physical
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.1- 1955- Volume(issue)/page/year: 34,116,1988
** MUTATION DATA **
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 500 ug/L
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
Volume(issue)/page/year: 21(2),59,1987
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3180
No. of Facilities: 167 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 1169 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M3180
No. of Facilities: 13 (estimated)
No. of Industries: 1
No. of Occupations: 9
No. of Employees: 567 (estimated)
No. of Female Employees: 13 (estimated)
*** STATUS IN U.S. ***
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***