*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XY3214000
CHEMICAL NAME           : as-Triazine, 3-amino-6-(2-(5-nitro-2-furyl)vinyl)-
CAS REGISTRY NUMBER     : 556-12-7
BEILSTEIN REFERENCE NO. : 0538900
LAST UPDATED            : 199612
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C9-H7-N5-O3
MOLECULAR WEIGHT        : 233.21
WISWESSER LINE NOTATION : T6NN DNJ CZ F1U1- BT5OJ ENW
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 3-Amino-6-(2-(5-nitro-2-furyl)vinyl)-as-triazine
   * 3-Amino-6-(2-(5-nitro-2-furyl)vinyl)-1,2,4-triazine
   * Furalazin
   * Furalazine
   * NFT
   * Panfuran
   * 1,2,4-Triazin-3-amine, 6-(2-(5-nitro-2-furanyl)ethenyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 83,778,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AACHAX Antimicrobial Agents and Chemotherapy (1961-70).  (Ann Arbor, MI)
   1961-70.  For publisher information, see AMACCQ.  Volume(issue)/page/year:
   -,275,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : >316 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EESADV Ecotoxicology and Environmental Safety.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1977-  Volume(issue)/page/year:
   6,149,1982
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 300 ug/L
REFERENCE :
   CJMIAZ Canadian Journal of Microbiology.  (National Research Council of
   Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 
     1954-  Volume(issue)/page/year: 11,185,1965
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,3,1974
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Protozoa - Euglena gracilis
DOSE/DURATION           : 2 mg/L
REFERENCE :
   JPROAR Journal of Protozoology.  (Soc. of Protozoologists, P.O. Box 368,
   Lawrence, KS 66044) V.1-    1954-  Volume(issue)/page/year: 17,129,1970

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: TRP reversion
   
   EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion
   
   EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay

 
                            *** END OF RECORD ***