*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XU5000000
CHEMICAL NAME : o-Toluidine, 4-chloro-
CAS REGISTRY NUMBER : 95-69-2
BEILSTEIN REFERENCE NO. : 0878505
REFERENCE : 4-12-00-01796 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 22
MOLECULAR FORMULA : C7-H8-Cl-N
MOLECULAR WEIGHT : 141.61
WISWESSER LINE NOTATION : ZR DG B1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 2-Amino-5-chlorotoluene
* Benzenamine, 4-chloro-2-methyl-
* Brentamine Fast Red TR Base
* 3-Chloro-6-aminotoluene
* 5-Chloro-2-aminotoluene
* 4-Chloro-2-methylaniline
* 4-Chloro-6-methylaniline
* 4-Chloro-2-methylbenzeneamine
* 4-Chloro-o-toluidine
* 4-Chloro-2-toluidine
* Daito Red Base TR
* Diazo Fast Red TRA
* Fast Red Base TR
* Fast Red 5CT Base
* Fast Red TR
* Fast Red TRO Base
* Kako Red TR Base
* Kambamine Red TR
* 2-Methyl-4-chloroaniline
* Mitsui Red TR Base
* Red Base NTR
* Red TR Base
* Sanyo Fast Red TR Base
* Tulabase Fast Red TR
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1058 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.1- 1976- Volume(issue)/page/year: 1,301,1976
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 310 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Gastrointestinal - nausea or vomiting
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.)
V.101-154, 1929-71. For publisher information, see ZHPMAT.
Volume(issue)/page/year: 110,12,1933
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - wild bird species
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 400 ug/plate
REFERENCE :
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave.,
New York, NY 10016) V.B11- 1976- Volume(issue)/page/year: 19,95,1984
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 200 nmol/plate
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 34,157,1986
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 250 mg/disc
REFERENCE :
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave.,
New York, NY 10016) V.B11- 1976- Volume(issue)/page/year: 19,95,1984
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 2 gm/disc
REFERENCE :
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave.,
New York, NY 10016) V.B11- 1976- Volume(issue)/page/year: 19,95,1984
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 1 mmol/L
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 11,184,1974
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 221,263,1989
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,305,1977
*** REVIEWS ***
IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 48,123,1990
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 30,61,1983
IARC Cancer Review:Group 2A
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 48,123,1990
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-FINLAND;Carcinogen JAN 1993
OEL-GERMANY;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 2 ppm (12 mg/m3);Skin;Carcinogen JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T0066
No. of Facilities: 77 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 1397 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0066
No. of Facilities: 16 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 250 (estimated)
No. of Female Employees: 250 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8896
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***