*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XU0175000
CHEMICAL NAME : Toluene, 2,4,6-trinitro-
CAS REGISTRY NUMBER : 118-96-7
LAST UPDATED : 199712
DATA ITEMS CITED : 54
MOLECULAR FORMULA : C7-H5-N3-O6
MOLECULAR WEIGHT : 227.15
WISWESSER LINE NOTATION : WNR B1 CNW ENW
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzene, 2-methyl-1,3,5-trinitro-
* Entsufon
* 2-Methyl-1,3,5-trinitrobenzene
* NCI-C56155
* TNT
* alpha-TNT
* TNT
* TNT-tolite
* Tolit
* Tolite
* 2,4,6-Trinitrotolueen
* Trinitrotoluene
* s-Trinitrotoluene
* sym-Trinitrotoluene
* 2,4,6-Trinitrotoluene
* s-Trinitrotoluol
* sym-Trinitrotoluol
* 2,4,6-Trinitrotoluol
* Tritol
* Triton
* Trojnitrotoluen
* Trotyl
* Trotyl oil
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-B011-150
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 28 gm/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Lungs, Thorax, or Respiration - cyanosis
Gastrointestinal - other changes
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,610,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 795 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 9,565,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 660 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 9,565,1982
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 1850 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
MRCSAB Special Report Series--Medical Research Council (United Kingdom).
(Her Majesty's Stationery Office, P.O. Box 569, London SE1 9NH, UK) No.1-
1915- Volume(issue)/page/year: 58,32,1921
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
MRCSAB Special Report Series--Medical Research Council (United Kingdom).
(Her Majesty's Stationery Office, P.O. Box 569, London SE1 9NH, UK) No.1-
1915- Volume(issue)/page/year: 58,32,1921
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - hypermotility, diarrhea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
MRCSAB Special Report Series--Medical Research Council (United Kingdom).
(Her Majesty's Stationery Office, P.O. Box 569, London SE1 9NH, UK) No.1-
1915- Volume(issue)/page/year: 58,32,1921
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - hypermotility, diarrhea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
MRCSAB Special Report Series--Medical Research Council (United Kingdom).
(Her Majesty's Stationery Office, P.O. Box 569, London SE1 9NH, UK) No.1-
1915- Volume(issue)/page/year: 58,32,1921
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7200 mg/kg/6W-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Related to Chronic Data - changes in testicular weight
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 55,343,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 11375 mg/kg/13W-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Blood - normocytic anemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 32,253,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3 gm/kg/30D-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - monoamine oxidase
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(10),57,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 11 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Blood - changes in spleen
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 9,565,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 182 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - normocytic anemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 9,565,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1456 mg/kg/26W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - normocytic anemia
Blood - changes in spleen
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 63,233,1990
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 5376 mg/kg
SEX/DURATION : male 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 9,565,1982
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A080-146
TYPE OF TEST : Body fluid assay
TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 262,167,1991
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 40 mg/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
20,103,1983
*** REVIEWS ***
ACGIH TLV-TWA 0.1 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 65,449,1996
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 65,449,1996
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 65,449,1996
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD778-725
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate
Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year:
1(1),93,1971
TOXICOLOGY REVIEW
PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 4,1,1952
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 ppm (0.5 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,270,1971
OSHA PEL (Gen Indu):8H TWA 1.50 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1.50 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1.50 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1.50 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.5 mg/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.5 mg/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.5 mg/m3;Skin JAN 1993
OEL-DENMARK:STEL 0.5 mg/m3;Skin JAN 1993
OEL-FINLAND:TWA 0.5 mg/m3;STEL 3 mg/m3;Skin JAN 1993
OEL-FRANCE:TWA 0.5 mg/m3;Skin JAN 1993
OEL-GERMANY:TWA 0.01 ppm (0.1 mg/m3);Skin;Carcinogen JAN 1993
OEL-HUNGARY:TWA 0.3 mg/m3;STEL 0.5 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg/m3;Skin JAN 1993
OEL-THE PHILIPPINES:TWA 1.5 mg/m3;Skin JAN 1993
OEL-RUSSIA:TWA 0.1 mg/m3;STEL 0.5 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.01 ppm (0.1 mg/m3);STEL 0.02 ppm;Skin JAN 1993
OEL-TURKEY:TWA 1.5 mg/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 0.5 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 2,4,6-TRINITROTOLUENE-air:10H TWA 0.5 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 74550
No. of Facilities: 10 (estimated)
No. of Industries: 2
No. of Occupations: 1
No. of Employees: 31 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
OSHA ANALYTICAL METHOD #44
*** END OF RECORD ***