*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XT5616800
CHEMICAL NAME           : p-Toluenesulfonamide, N-chloro-, sodium salt
CAS REGISTRY NUMBER     : 127-65-1
LAST UPDATED            : 199710
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C7-H8-Cl-N-O2-S.Na
MOLECULAR WEIGHT        : 228.66
WISWESSER LINE NOTATION : GMSWR DI &-NA-
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Acti-chlore
   * Aktivin
   * Anexol
   * Benzenesulfonamide, N-chloro-4-methyl-, sodium salt
   * Berkendyl
   * Chloralone
   * Chloramine T
   * Chlorasan
   * Chloraseptine
   * Chlorazan
   * Chlorazene
   * Chlorazone
   * N-Chloro-4-methylbenzenesulfonamide sodium salt
   * Chlorozone
   * Chlorseptol
   * Clorina
   * Clorosan
   * Desinfect
   * Euclorina
   * Gansil
   * Gyneclorina
   * Halamid
   * Heliogen
   * Kloramin
   * Kloramine-T
   * Multichlor
   * Sodium chloramine T
   * Sodium p-toluenesulfonylchloramide
   * Sodium tosylchloramide
   * Tampules
   * Tochlorine
   * Tolamine
   * Tosylchloramide sodium
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 14,259,1920
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 14,259,1920
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Behavioral - muscle weakness
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 14,259,1920
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 14,259,1920
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 255 ug/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,349,1991
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 ppm/24H
REFERENCE :
   ARMCAH Annual Review of Medicine.  (Annual Reviews, Inc., POB 10139, Palo
   Alto, CA 94303) V.1-    1950-  Volume(issue)/page/year: 21,409,1970

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83916
       No. of Facilities: 93 (estimated)
       No. of Industries: 2
       No. of Occupations: 5
       No. of Employees: 378 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83916
       No. of Facilities: 190 (estimated)
       No. of Industries: 7
       No. of Occupations: 8
       No. of Employees: 1829 (estimated)
       No. of Female Employees: 1284 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***