*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XS3650000
CHEMICAL NAME           : m-Toluamide,
                          alpha-(2-chloro-4-(4,6-diamino-2,2-dimethyl-s-triazin
                          e-1(2H)-yl)phenoxy)- N,N-dimethyl-, ethanesulfonate
CAS REGISTRY NUMBER     : 41191-04-2
LAST UPDATED            : 199707
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C21-H25-Cl-N6-O2.C2-H6-O3-S
MOLECULAR WEIGHT        : 539.11
WISWESSER LINE NOTATION : T6N CN EN BHJ AR CG BO1R CVN1&1&& B1 B1 DZ FZ &WSQ2
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * BAF
   * Baker's Antifol
   * Baker's Antifolante
   * NSC 139105
   * Triazinate
   * TZT
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1355 mg/kg/13W-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   ARDEAC Archives of Dermatology.  (AMA, 535 N. Dearborn St., Chicago, IL
   60610)  V.82-    1960-  Volume(issue)/page/year: 121,232,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 24 mg/kg/5D
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - thrombocytopenia
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 38,690,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - nausea or vomiting
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 40,9,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 8 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Blood - changes in bone marrow (not otherwise specified)
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,48,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 58600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 2 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,3659,1976
 
                            *** END OF RECORD ***