*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XP3582990
CHEMICAL NAME           : Thyroxine, monosodium salt, D-
CAS REGISTRY NUMBER     : 137-53-1
LAST UPDATED            : 199709
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C15-H10-I4-N-O4.Na
MOLECULAR WEIGHT        : 798.85
WISWESSER LINE NOTATION : QR BI FI DOR BI FI D1YZVO &-NA-
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Human
                          Hormone
SYNONYMS/TRADE NAMES :
   * Biotirmone
   * Choloxin
   * Debetrol
   * Dethyrona
   * Detyroxin
   * Dextroid
   * Dextrothyroxine sodium
   * Dextroxin
   * Dynothel
   * Lisolipin
   * Nadrothyron D
   * Sodium dextrothyroxine
   * Sodium D-T4
   * Sodium D-thyroxine
   * 3:5:3':5'-Tetraiodo-D-thyronine sodium
   * D-Thyroxine sodium salt
   * D-T4 sodium
   * Travenon
   * D-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 12 ug/kg/12D-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Liver - liver function tests impaired
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   JJMDAT Japanese Journal of Medicine.  (Nankodo Co., Ltd., POB 5272, Tokyo
   International 100-31, Japan)  V.1-30, 1962-1991.  For publisher information,
   see IEDIEP.  Volume(issue)/page/year: 23,282,1984
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg/30D-C
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 29,207,1970
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 222 mg/kg/24W-C
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
   Kidney, Ureter, Bladder - changes in bladder weight
   Endocrine - evidence of thyroid hyperfunction
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 29,565,1970
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 29 mg/kg
SEX/DURATION            : female 1-29 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   DABBBA Dissertation Abstracts International, B: The Sciences and
   Engineering.  (University Microfilms International, 300 N. Zeeb Rd., Ann
   Arbor, MI 48106)  V.30-    1969-  Volume(issue)/page/year: 32,1182,1971
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 15 mg/kg
SEX/DURATION            : female 15-29 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - physical
REFERENCE :
   DABBBA Dissertation Abstracts International, B: The Sciences and
   Engineering.  (University Microfilms International, 300 N. Zeeb Rd., Ann
   Arbor, MI 48106)  V.30-    1969-  Volume(issue)/page/year: 32,1182,1971
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 16 mg/kg
SEX/DURATION            : female 16-31 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   SDMEAL South Dakota Journal of Medicine.  (South Dakota Medical Assoc., 608
   West Ave. N, Sioux Falls, SD 57104)  V.18-     1965-
   Volume(issue)/page/year: 21,33,1968

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5407
       No. of Facilities: 9 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 63 (estimated)
       No. of Female Employees: 9 (estimated)

 
                            *** END OF RECORD ***