*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XN6237000
CHEMICAL NAME           : Thiosporin
CAS REGISTRY NUMBER     : 1407-09-6
LAST UPDATED            : 199007
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Polymyxin B methanesulfonate
   * Polymyxin B methanesulfonic acid
   * Polymyxin B, N-sulfomethyl deriv., sodium salt
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 23,552,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 137 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   INURAQ Investigative Urology.  (Baltimore, MD)  V.1-19, 1963-81.  For
   publisher information, see JOURAA.  Volume(issue)/page/year: 6,505,1969
 
                            *** END OF RECORD ***