*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XJ9095000
CHEMICAL NAME           : 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide,
                          6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-,
                          1,1-dioxide
CAS REGISTRY NUMBER     : 70374-39-9
BEILSTEIN REFERENCE NO. : 1039965
LAST UPDATED            : 199806
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C13-H10-Cl-N3-O4-S2
MOLECULAR WEIGHT        : 371.83
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Chlortenoxicam
   * CTX
   * Lornoxicam
   * Lornoxicam
   * Ro 13-9297
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5730 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   94,61,1989
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 58240 ug/kg/1Y-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - pigmented or nucleated red blood cells
   Related to Chronic Data - death
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   35,909,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 42 mg/kg/6W-I
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
   Gastrointestinal - hypermotility, diarrhea
   Related to Chronic Data - death
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   35,465,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 192 mg/kg/52W-I
TOXIC EFFECTS :
   Gastrointestinal - alteration in gastric secretion
   Blood - other changes
   Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   35,465,1997
 
                            *** END OF RECORD ***