*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XJ9089200
CHEMICAL NAME : Thieno(3,2-c)pyridine,
4,5,6,7-tetrahydro-5-((2-chlorophenyl)methyl)-
CAS REGISTRY NUMBER : 55142-85-3
BEILSTEIN REFERENCE NO. : 1216802
LAST UPDATED : 199712
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C14-H14-Cl-N-S
MOLECULAR WEIGHT : 263.80
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* 5-((2-Chlorophenyl)methyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine
* PCR 5332
* Ticlopidine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 336 mg/kg/47D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Blood - agranulocytosis
Blood - thrombocytopenia
REFERENCE :
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696,
Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 28,1236,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 600 mg/kg/60D-I
TOXIC EFFECTS :
Blood - aplastic anemia
Blood - changes in bone marrow (not otherwise specified)
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013,
Israel) V.1- 1965- Volume(issue)/page/year: 31,444,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 429 mg/kg/6OD-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,407,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 100 mg/kg/10D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - urine volume decreased
Blood - eosinophilia
REFERENCE :
AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc.,
Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1981-
Volume(issue)/page/year: 25,934,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1780 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - pleural thickening
Skin and Appendages - hair
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2,
1983-84. For publisher information, see NCDREP. Volume(issue)/page/year:
1,295,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - pleural thickening
Skin and Appendages - hair
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2,
1983-84. For publisher information, see NCDREP. Volume(issue)/page/year:
1,295,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 70 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - pleural thickening
Skin and Appendages - hair
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2,
1983-84. For publisher information, see NCDREP. Volume(issue)/page/year:
1,295,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - pleural thickening
Skin and Appendages - hair
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2,
1983-84. For publisher information, see NCDREP. Volume(issue)/page/year:
1,295,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1250 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - pleural thickening
Skin and Appendages - hair
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2,
1983-84. For publisher information, see NCDREP. Volume(issue)/page/year:
1,295,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 88 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - pleural thickening
Skin and Appendages - hair
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2,
1983-84. For publisher information, see NCDREP. Volume(issue)/page/year:
1,295,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : >6 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - pleural thickening
Skin and Appendages - hair
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2,
1983-84. For publisher information, see NCDREP. Volume(issue)/page/year:
1,295,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - pleural thickening
Skin and Appendages - hair
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2,
1983-84. For publisher information, see NCDREP. Volume(issue)/page/year:
1,295,1983
*** END OF RECORD ***