*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XJ9088200
CHEMICAL NAME           : 1H-Thieno(3,4-d)imidazole-4-pentanoic acid,
                          hexahydro-2-oxo-, (3aS-(3a-alpha,4-beta, 6a-alpha))-
CAS REGISTRY NUMBER     : 58-85-5
LAST UPDATED            : 199706
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C10-H16-N2-O3-S
MOLECULAR WEIGHT        : 244.34
WISWESSER LINE NOTATION : T55 BMVM GSTJ H4VQ
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Bioepiderm
   * Bios II
   * Biotin
   * (+)-Biotin
   * d-Biotin
   * D-Biotin
   * D-(+)-Biotin
   * Coenzyme R
   * Factor S
   * Factor S (vitamin)
   * Vitamin B7
   * Vitamin H
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 mg/kg
SEX/DURATION            : female 14-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JNSVA5 Journal of Nutritional Science and Vitaminology.  (Business Center
   for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan)  V.19-
   1973-  Volume(issue)/page/year: 22,181,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   CUSCAM Current Science.  (Current Science Assoc., Sadashivanagar P.O.,
   Bangalore 560 080, India) V.1-    1932-  Volume(issue)/page/year:
   42,613,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 mg/kg
SEX/DURATION            : female 1-2 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JNSVA5 Journal of Nutritional Science and Vitaminology.  (Business Center
   for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan)  V.19-
   1973-  Volume(issue)/page/year: 21,89,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 17 mg/kg
SEX/DURATION            : female 1-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 52,149,1996

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80381
       No. of Facilities: 129 (estimated)
       No. of Industries: 2
       No. of Occupations: 8
       No. of Employees: 8306 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80381
       No. of Facilities: 1674 (estimated)
       No. of Industries: 9
       No. of Occupations: 41
       No. of Employees: 46583 (estimated)
       No. of Female Employees: 22672 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***