*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI7552000
CHEMICAL NAME           : Thiamine, trihydrogen pyrophosphate (ester)
CAS REGISTRY NUMBER     : 154-87-0
LAST UPDATED            : 199806
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C12-H19-N4-O7-P2-S.Cl
MOLECULAR WEIGHT        : 460.80
WISWESSER LINE NOTATION : T6N CNJ B1 DZ E1- AT5K CSJ D2OPQO&OPQQO E1 &G
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Berolase
   * Biosyth
   * Bioxylasi
   * Bivitasi
   * B-Neurox
   * Co-Bi
   * Cocarbina
   * Cocarboxil
   * Cocarboxylase
   * Coenbione
   * Coxylase
   * Diphosphothiamin
   * Diphosphothiamine
   * Farmaneurina
   * Metabolase
   * Nutrase
   * Pyrolase
   * Pyruvodehydrase
   * TDP (thiamin ester)
   * Thiaminediphosphate
   * Thiamine-PP
   * Thiaminepyrophosphate
   * Thiamine pyrophosphate chloride
   * Thiamine pyrophosphoric ester
   * Thiaminpyrophosphate
   * TPP (coenzyme)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,471,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 465 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,471,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - sensory change involving peripheral nerve
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 19,1025,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,471,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,471,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - sensory change involving peripheral nerve
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 19,1025,1985

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X3828
       No. of Facilities: 172 (estimated)
       No. of Industries: 1
       No. of Occupations: 5
       No. of Employees: 850 (estimated)
       No. of Female Employees: 766 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***