*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XJ4500000
CHEMICAL NAME           : Thiazole,
                          2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 1155-03-9
LAST UPDATED            : 199706
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C15-H21-N3-O-S.Cl-H
MOLECULAR WEIGHT        : 327.91
WISWESSER LINE NOTATION : T5N CSJ BN1R DO1&2N1&1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 194-B
   * 2-((2-(Dimethylamino)ethyl)-(p-methoxybenzyl)amino)thiazole  
   monohydrochloride
   * 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)thiazole hydrochloride
   * N,N-Dimethyl-N'-(p-methoxybenzyl)-N'-(2-thiazolyl)-ethylenediamine  
   monohydrochloride
   * 1,2-Ethanediamine,  
   N-((4-methoxyphenyl)methyl)-N',N'-dimethyl-N-2-thiazolyl-, HCl
   * Zolamine hydrochloride
   * WL-291
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 570 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
                            *** END OF RECORD ***