*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XJ1261340
CHEMICAL NAME           : 4H-1,3-Thiazin-4-one,
                          tetrahydro-2-(o-chlorophenyl)-3-methyl-, 1,1-dioxide
LAST UPDATED            : 198605
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C11-H12-Cl-N-O3-S
MOLECULAR WEIGHT        : 273.75
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Tetrahydro-2-(o-chlorophenyl)-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - ataxia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 122,517,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 940 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - ataxia
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 122,517,1957
 
                            *** END OF RECORD ***