*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI3654000
CHEMICAL NAME           : 1,3,4-Thiadiazole, 2-amino-5-(2-thienyl)-,
                          hydrochloride, hydrate
CAS REGISTRY NUMBER     : 102367-70-4
LAST UPDATED            : 199512
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C6-H5-N3-S2.Cl-H.H2-O
MOLECULAR WEIGHT        : 237.74
WISWESSER LINE NOTATION : T5NN DSJ CZ E- BT5SJ &GH &QH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2-Amino-5-(2-thienyl)-1,3,4-thiadiazole hydrochloride hydrate
   * 2-Amino-5-(2-tienil)-1,3,4-tiadiazolo cloridrato idrato
   * L 1458
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 374 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - tremor
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 13,187,1958
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 21420 mg/kg/17W-I
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 13,357,1958
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2800 mg/kg/2W-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Autonomic Nervous System - other (direct) parasympathomimetic
   Blood - changes in cell count (unspecified)
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 13,357,1958
 
                            *** END OF RECORD ***