*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI3620000
CHEMICAL NAME           : 1,3,4-Thiadiazole, 2-amino-5-phenyl-, hydrochloride,
                          hydrate
CAS REGISTRY NUMBER     : 102367-68-0
LAST UPDATED            : 199512
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C8-H7-N3-S.Cl-H.H2-O
MOLECULAR WEIGHT        : 231.72
WISWESSER LINE NOTATION : T5NN DSJ CZ ER &GH &QH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2-Amino-5-fenil-1,3,4-tiadiazolo cloridrato idrato
   * 2-Amino-5-phenyl-1,3,4-thiadiazole hydrochloride hydrate
   * L 1460
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 264 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 13,187,1958
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2100 mg/kg/2W-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Autonomic Nervous System - other (direct) parasympathomimetic
   Blood - changes in other cell count (unspecified)
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 13,357,1958
 
                            *** END OF RECORD ***