*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI0389900
CHEMICAL NAME           : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic
                          acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)
                          thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-
CAS REGISTRY NUMBER     : 25953-19-9
BEILSTEIN REFERENCE NO. : 4169371
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C14-H14-N8-O4-S3
MOLECULAR WEIGHT        : 454.54
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Cefamezin
   * Cefazolin
   * Cefazoline
   * Cephamezine
   * Cephazolin
   * Cephazoline
   * CEZ
   * Elzogram
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BYYADW Byoin Yakugaku. Hospital Pharmacology.  (Yakuji Nippon Sha, 1-11
   Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-    1975-
   Volume(issue)/page/year: 3,220,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BYYADW Byoin Yakugaku. Hospital Pharmacology.  (Yakuji Nippon Sha, 1-11
   Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-    1975-
   Volume(issue)/page/year: 3,220,1978
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 164 gm/kg/26W-I
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   28(Suppl 7),1089,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 44100 mg/kg/35D-I
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
   Related to Chronic Data - death
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   28(Suppl 7),1007,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 11200 mg/kg/28D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   BYYADW Byoin Yakugaku. Hospital Pharmacology.  (Yakuji Nippon Sha, 1-11
   Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-    1975-
   Volume(issue)/page/year: 3,220,1978

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - A1317
       No. of Facilities: 33 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 528 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - A1317
       No. of Facilities: 318 (estimated)
       No. of Industries: 1
       No. of Occupations: 5
       No. of Employees: 16111 (estimated)
       No. of Female Employees: 13596 (estimated)

 
                            *** END OF RECORD ***