*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI0383750
CHEMICAL NAME           : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic
                          acid,
                          7-((hydroxyphenylacetyl)amino)-8-oxo-3-(((1-sulfometh
                          yl)-1H-tetrazol-5-yl) thio)methyl)-,
                          (6R-(6-alpha,7-beta(R*)))-
CAS REGISTRY NUMBER     : 61270-58-4
BEILSTEIN REFERENCE NO. : 1066181
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C18-H18-N6-O8-S3
MOLECULAR WEIGHT        : 542.60
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Cefonicid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 40 mg/kg/2D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - hematuria
   Blood - hemorrhage
   Blood - tumors
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   123,472,1995
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 83 gm/kg/13W-I
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - thrombocytopenia
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   90,143,1981

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5274
       No. of Facilities: 7 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 307 (estimated)
       No. of Female Employees: 251 (estimated)

 
                            *** END OF RECORD ***