*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI0367350
CHEMICAL NAME           : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic
                          acid,
                          7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-
                          3-((2,3-dihydro-2-(2-
                          hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-,
                          monosulfate, (6R-(6-alpha,7-beta(Z)))-
LAST UPDATED            : 199603
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H22-N8-O6-S2.H2-O4-S
MOLECULAR WEIGHT        : 620.69
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Cefoselis sulfate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,561,1995
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,561,1995
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 91 gm/kg/13W-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Blood - normocytic anemia
   Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,561,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 16380 mg/kg/13W-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Blood - changes in bone marrow (not otherwise specified)
   Blood - other changes
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,561,1995
 
                            *** END OF RECORD ***