*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI0196400
CHEMICAL NAME           : 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic
                          acid, 3-(aminomethyl)-6-(1-hydroxyethyl)-7- oxo-,
                          (5R-(5-alpha,6-alpha(R*)))-
CAS REGISTRY NUMBER     : 107740-67-0
BEILSTEIN REFERENCE NO. : 5059799
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C9-H12-N2-O4-S
MOLECULAR WEIGHT        : 244.29
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Antibiotic CGP 31608
   * CGP 31608
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27300 mg/kg/13W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 17,801,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18200 mg/kg/26W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 17,801,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 5460 mg/kg/13W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 17,801,1989
 
                            *** END OF RECORD ***