*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI0115000
CHEMICAL NAME           : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
                          6-(((((3,5-dioxo-1-piperazinyl)carbonyl)
                          amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-,
                          (2S-(2-alpha,5-alpha,6-beta(S*)))-
CAS REGISTRY NUMBER     : 59703-78-5
BEILSTEIN REFERENCE NO. : 1063250
LAST UPDATED            : 199806
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H23-N5-O7-S
MOLECULAR WEIGHT        : 489.55
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Desethylpiperacillin
   * Desethyl-PIPC
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 19(Suppl
   2),281,1994
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11200 mg/kg/28D-I
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Blood - changes in other cell count (unspecified)
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 19(Suppl
   2),281,1994
 
                            *** END OF RECORD ***